http://20.198.91.3:8080/jspui/handle/123456789/169 Sun, 05 Apr 2026 17:05:25 GMT 2026-04-05T17:05:25Z http://20.198.91.3:8080/jspui/handle/123456789/9048 Title: A critical overview of the global arthroplasty practices from patients point-of-view Authors: Banerjee, Souradip Sun, 01 Jan 2023 00:00:00 GMT http://20.198.91.3:8080/jspui/handle/123456789/9048 2023-01-01T00:00:00Z http://20.198.91.3:8080/jspui/handle/123456789/9047 Title: Virtual screening of phytochemicals to highlight the hit molecules for skin lightening formulations Authors: Chowdhary, Meghant Prasad Abstract: In molecular biology and drug discovery, the capacity to anticipate the binding conformation of ligands within receptors is of utmost relevance. The computational method known as molecular docking is essential to this procedure since it is capable of making precise predictions about ligand-receptor interactions. The objective of this thesis is to enhance molecular docking algorithms, and explore their possible applications. For lighter skin appearance, skin whitening products are available commercially - Melasma and Postinflammatory hyperpigmentation are the major disorder of this. These all are treated by whitening agents which acts as various levels of melanin production in the skin. The enzyme tyrosinase plays a major role in this known as competitive inhibitors of tyrosinase (the key enzyme in melanogenesis). In this study we elucidated how natural whitening products may decrease the pigmentation in skin and evaluate the potential tyrosinase, collagenase and elastase inhibitory activities of phytochemicals. Sun, 01 Jan 2023 00:00:00 GMT http://20.198.91.3:8080/jspui/handle/123456789/9047 2023-01-01T00:00:00Z http://20.198.91.3:8080/jspui/handle/123456789/9046 Title: Identifying the hit molecules as multi-targeted inhibitors of common cancer receptors from a library of phytochemicals Authors: Majumdar, Avik Abstract: Understanding how ligands will attach to receptors is crucial for both molecular biology and medication development. Due to its ability to anticipate ligand-receptor interactions precisely, this approach necessitates the use of the computational method known as molecular docking. In order to evaluate several phytochemicals as prospective anti-cancer medications and take into account their potential applications, this thesis will look at them. A new comparative investigation reveals that just 3.4% of cancer treatments are effective, compared to a success rate of 20.9% for all oncology medications. Although there were numerous anti-cancer medications available at the time, the basic issue is that they are less effective than other oncology drugs, which have a success rate of 20.9%. In addition, not all cancer drugs that pass Phase III trials necessarily offer a therapeutic benefit to a wider population. The immune system is also stimulated by such treatments, which has a number of negative consequences including anemia, diarrhea, appetite loss etc. To find more potent anti-cancer drugs, further investigation is being done. These phytochemicals are produced by a wide variety of plants and have beneficial medicinal properties. These plants are mentioned in Ayurveda as well. The names of several medicinal plants may also be found in Indian Medicinal Plants, Phytochemistry and Therapeutics. There are 4010 Indian medicinal plants, 17967 phytochemicals, and 1095 therapeutic uses present in the IMPPAT database. Our objective was to find phytochemicals that may combat cancer more successfully and with fewer side effects. To achieve this, molecular docking is a great method for examining the bonds between protein and phytochemicals. The most wellliked and useful tool for molecular docking is AutoDock Vina. SwissADME is a tool that allows us to assess the ligand's ADMET qualities, such as its solubility, BB penetration, and GI absorption level, as well as whether the ligand (in this example, a phytochemical) violates Lipinski's rule of five for the possibility that a molecule is a medication. Sun, 01 Jan 2023 00:00:00 GMT http://20.198.91.3:8080/jspui/handle/123456789/9046 2023-01-01T00:00:00Z http://20.198.91.3:8080/jspui/handle/123456789/9045 Title: Stimulus-driven spectral and temporal analysis of ecg, eeg and emg signals Authors: Das, Sanjoy Kumar Sun, 01 Jan 2023 00:00:00 GMT http://20.198.91.3:8080/jspui/handle/123456789/9045 2023-01-01T00:00:00Z